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Das SR, et al

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High glucose may contribute to impaired autophagy and increased senescence in PTECs, resulting in the accumulation of unfolded proteins and defective organelles (101)

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Some studies suggest reduced effectiveness in individuals with higher body mass index (BMI), though evidence is mixed and the FDA has not required labeling changes regarding weight

Clin Chim Acta 275 : 175184 Rennard SI, Basset G, Lecossier D, O'Donnell KM, Pinkston P, Martin PG, Crystal RG 1986 Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution