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Neurodegeneration and AD models: exenatide Considering the successful neuroprotection of GLP-1RAs in in vivo diabetic models, researchers have directly tested GLP-1RAs in in vivo models of neurodegenerative diseases, including toxin-induced and transgenic models

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doi: 10.1016/j.bbr.2012.09.021 145 HayesMRLeichnerTMZhaoSLeeGSChowanskyAZimmerDet al

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The biggest factors include: Peptide structure Half-life Dosage Injection frequency Kidney and liver function Metabolism Body composition Whether the peptide is short-acting or long-acting Certain peptides are designed with structural changes that slow how quickly the body clears them