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[6] Because IGF-1 LR3 retains strong IGF-1R affinity, it initiates the same receptor activation cascade the difference lies in bioavailability, not in the fundamental signaling logic

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Because the oral microbiome interacts directly with the immune system, sustained microbial imbalance in the mouth can drive chronic low-grade inflammation that extends beyond the oral cavity

At 60, Sinclair's blood markers now match those of a 31-year-old