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Additionally, genetic variants in the phosphodiesterase 8B ( PDE8B ) gene, which encodes a high-affinity cAMP-specific phosphodiesterase, as genetic modulators of TSH levels (30, 31), and in the TSH receptor (32) may also influence the setpoint of the HPT axis, potentially contributing to diminished cellular responsiveness to circulating thyroid hormones

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One crucial function it provides is the production of red blood cells, which carry oxygen throughout the body for various functions

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