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In addition to TCR engagement by peptide MHC complexes, optimal T-cell activation and proliferation generally requires co-stimulatory signals provided by interaction between CD28 or CTLA-4 on T-cells and their ligands CD80 or CD86 on professional APC

While both drugs are usually covered for type 2 diabetes, getting approval for weight management is a different matter

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Brain Pathol (Zurich, Switzerland) 24:261269

Risk-of-bias reduction strategies such as robust randomization methods, allocation concealment, blinding of outcome assessors, and intention-to-treat analysis should be incorporated to improve internal validity and reproducibility

Researchers from Japan have found that a novel member of a class of anti-diabetes drugs could be the key to treating patients with muscle wasting disease