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High stress, poor sleep, and emotional triggers can reactivate it and override some of the medication's calming effect

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rates and severity in broader clinical practice may differ

Front Plant Sci 7:609 Rossel JB, Walter PB, Hendrickson L, Chow WS, Poole A, Mullineaux PM, Pogson BJ (2006) A mutation affecting ascorbate peroxidase 2 gene expression reveals a link between responses to high light and drought tolerance

Phase 2 trial data showed no plateau at the 48-week endpoint