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While further studies are underway to assess their efficacy for opioid, cocaine, and stimulant use disorders, current findings suggest that GLP-1 RAs may offer new avenues for addressing maladaptive reward-driven behaviors beyond obesity

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10 Proof-of-concept treatments were validated in Pfa1 cells, which were knocked out of endogenous GPX4 and transfected to overexpress murine mScarlet-tagged GPX4 WT (red) or GPX4 R152H (blue)

In addition, PFKFB3 plays the same important but different functions in macrophages and dendritic cells

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Zhang F, Lau SS, Monks TJ