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These work locally by drawing water into the rectum and lubricating stool

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This methylation reaction serves important regulatory functions but also depletes NAD+ by converting it to compounds that cannot participate in NAD+-dependent metabolism

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Indian J Ophthalmol 64(5):346357 Prajna NV et al (2016) Effect of oral Voriconazole on fungal keratitis in the mycotic ulcer treatment trial II (MUTT II): a randomized clinical trial