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The authors hoped their GLP-1 agonist Lixisenatide would reach this threshold

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2019 May 1;18(5):454-459

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Outcomes outside of the testing hierarchy, such as occurrence of diabetes-related morbidity (e.g., individual component of MACE or expanded composite CV outcome), change in blood pressure, and HRQoL, need to be interpreted with caution due to the possible inflated type I error