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p = 0.0051)

Similar to other neurotrophins, BDNF is first synthesized as a precursor protein, named pro-BDNF of 32 KDa, which is cleaved by different proteases to produce either the mature form of 14 KDa, or the truncated form of 28 KDa

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Recombinant HGH, by contrast, is the finished hormone administered directly, bypassing the pituitary and its feedback controls entirely

doi: 10.1021/tx034106u

Unlike some medications that lose effectiveness over time, incretin-based therapies maintain efficacy in multi-year studies