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The STEP 1 trial showed 14.9% weight loss at 2.4 mg/week over 68 weeks (Wilding et al., 2021)

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In diabetic patients, higher glucose levels and greater glycemic variability promote a pro-inflammatory state, which leads to defects in microvasculature characteristic of DR [78]

Oral GLP1s are a highpriority class for metabolic disease (obesity, type 2 diabetes) and Hengruis move signals Chinas accelerating push to develop homegrown oral GLP1 therapies amid global competition and mixed results from some multinational programs

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