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In Canada, it is frequently prescribed by family doctors to help manage high cholesterol levels and reduce the risk of cardiovascular events

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The exact mechanisms behind this response are not fully understood, but it is believed that caffeine can influence hormones such as ghrelin and leptin, which regulate hunger and satiety

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Physiopathological consequences with clinical expression have been observed in different systems, such as that recently found by Chang-Hoon et al., in which patients with fatty liver had lower lung function as measured by FVC [45]

At the level of precursor lesions such as nevi, the initial mutagenic events triggering the neoplastic transformation are represented by several mutations which lead to the activation of the MAPK pathway (such as BRAF V600E), while at an intermediate stage of tumour progression, NRAS and additional driver mutations are seen