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Categorical outcomes were derived from imputed continuous outcomes

In Drosophila fat cells, inhibiting dSERCA promotes lipodystrophy, aberrant LD formation and ectopic lipid accumulation by regulating intracellular Ca 2+ homeostasis [18]

Finally, establish realistic timelines for metabolic improvements, recognizing that benefits typically emerge gradually over several months of treatment

In the documented protocol, daily during the 4-week activation phase, then 5/week for weeks 58, then 23/week for maintenance

For hepatocyte-specific Gdh1 deletion, Glud1 fl/fl mice received a tail-vein injection of AAV8-TBG-GFP (Addgene, 105535) or AAV8-TBG-Cre (1.5 10 11 genome copies per mouse

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