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The citric acid cycle involves three NAD+-dependent dehydrogenase reactions: isocitrate dehydrogenase, -ketoglutarate dehydrogenase, and malate dehydrogenase, each generating NADH while releasing carbon dioxide and regenerating oxaloacetate for continued cycle operation
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This means that it can be effectively absorbed into the bloodstream when administered orally, allowing for convenient and non-invasive therapeutic administration
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