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It is to be noted that our cryo-EM analysis also revealed minor structural classes of particles with different conformations besides the ghrelin- and ibutamoren-GHSR-G i complexes with the 2.7 cryo-EM maps (Supplementary Fig

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A few factors were identified as responsible for weight regain after cessation of treatment, including the CNS, deterioration of the activity of the cells secreting hormones, and transient hormonal adaptation to weight loss (Table 1)