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Leveraging human genetic data to investigate the cardiometabolic effects of glucose-dependent insulinotropic polypeptide signalling

Before starting any weight management strategydietary program, compounded GLP-1, or combined approachqualified healthcare providers should evaluate metabolic history, medication interactions, kidney and liver function, and gastrointestinal health

95% CI 0.79 1.16

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While the decrease in HbA1c levels reached a plateau at 24 weeks, weight loss in the 2 studies was progressive without evidence of attenuation effect up to the end of follow-up at 36-48 weeks

Best results come with healthy eating, physical activity, and ongoing provider supervision these medications are not a stand-alone solution