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Multiple randomized controlled trials demonstrate that GLP-1 receptor agonists produce 15-22% average body weight loss over 68 weeks, with cardiovascular benefits including reduced blood pressure and improved metabolic markers

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T(3) stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice

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Abstract Dopamine directly acts in the liver and white adipose tissue (WAT) to regulate insulin signaling, glucose uptake, and catabolic activity