Common GLP-1 medications and their approved uses include: Ozempic (semaglutide): for type 2 diabetes, used off-label for weight loss Wegovy (semaglutide): approved for chronic weight management Mounjaro (tirzepatide): for type 2 diabetes, with growing use for weight loss
A focused literature search for NMAs dealing with Wegovy (semaglutide) and weight management was run in MEDLINE All (1946-) on April 6, 2022
Its mechanism includes: Releasing norepinephrine in the hypothalamus, suppressing appetite Potentially modestly increasing energy expenditure , though appetite suppression is the primary mechanism Providing mild stimulant effects that may reduce fatigue associated with calorie restriction Phentermine typically produces more rapid appetite suppression but is generally recommended for short-term use in countries where it is licensed
[4] US Food and Drug Administration
Taking it on an empty stomach, 30 to 60 minutes before eating, is crucial for the strongest effect
These medications work by mimicking the natural GLP-1 hormone, which slows gastric emptying, reduces appetite, and improves glycaemic control
