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As these medications become among the most widely prescribed in the world, the ability to tailor treatment based on genetic profile or to target specific clinical outcomes such as cardiovascular risk reduction could transform prescribing practices well beyond their current primary use in obesity and diabetes management Sources New 23andMe Research Institute Study Identifies Genetic Predictors for GLP-1 Weight Loss Efficacy and Side Effects 23andME April 8, 2026 Genetic variations linked to weight loss, side effects from GLP-1 drugs Reuters April 10, 2026
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Meloni AR, DeYoung MB, Han J, Best JH, Grimm M: Treatment of patients with type 2 diabetes with exenatide once weekly versus oral glucose-lowering medications or insulin glargine: achievement of glycemic and cardiovascular goals
Importantly, in the last decade, a paradigm shift occurred in the field of the microbiota-gut-brain axis highlighting the need to move towards functional approaches for the assessment of gut microbes that goes beyond just compositional alterations [226]
The choice of manufacturing approach depends on factors such as peptide length, complexity, and required production volumes
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