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They mimic the effects of endogenous GLP-1, which is produced in the intestines in response to food intake, and by activating the GLP-1 receptor they enhance glucose-dependent insulin secretion, inhibit glucagon release, and slow gastric emptying

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Phentermine is contraindicated in people with a history of coronary artery disease, stroke, arrhythmias, congestive heart failure or uncontrolled hypertension, and within 14 days of a monoamine oxidase inhibitor because of hypertensive crisis risk

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