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It's by no means a guarantee that a lower dose translates to lower side effects, he says

A shortage of medication can be particularly concerning for people on GLP-1s considering that research shows that people who stop taking certain GLP-1s are likely to regain weight without the medication

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Physical activities become easier

There are some potential biases in these data that we need to be cautious about, but this gives us some valuable insights about the risk profile of these agents that can inform subsequent studies perhaps even a randomized controlled trial that can tease out the specific mechanisms and provide more conclusive evidence. Reduced risk overall GLP-1 receptor agonists have been approved in the United States to treat diabetes since 2005 and obesity since 2014