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These results translated to significant proportions of participants achieving clinically meaningful weight loss: 5% or More Weight Reduction: 92% (4 mg), 100% (8 mg), 100% (12 mg), and 27% (placebo) 10% or More Weight Reduction: 75% (4 mg), 91% (8 mg), 93% (12 mg), and 9% (placebo) 15% or More Weight Reduction: 60% (4 mg), 75% (8 mg), 83% (12 mg), and 2% (placebo) These data underscore retatrutides potential to deliver unprecedented weight loss in a significant portion of individuals with obesity

However, keto diets are generally easier to sustain long-term because they allow more food variety, including vegetables and healthy fats

GLP-1 injections can cause side effects, so its recommended to start with a low dose and gradually increase it over time to reach the target dose

adjust fibre appropriately (increase gradually for constipation, reduce insoluble fibre temporarily for diarrhoea)

Bleeding risk is ginkgo's most important safety issue

Moreover, fennel is a phytoestrogen and has been studied to recognize its potential to regulate menstrual cycles and improve metabolic health in women with PCOS [35]