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It exists precisely because the jump from 1.0mg to 2.4mg is large, and not every researcher tolerates it well

Notably, vitamin B6-related metabolomic studies focus on the exploration of biomarkers for PDE, and relevant differential metabolites have been detected in biofluids (135137, 147)

Although the G6PD deficiency is rare, its prevalence in the regions where malaria is common would be over 10% [14]

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Importantly, DSIP exhibits significant inter-individual variability in effects, which may reflect genetic differences in metabolism, receptor expression, or endogenous regulatory systems