If prednisone is essential, ask your prescriber whether a lower maintenance dose exists, or whether alternative anti-inflammatory medications with less appetite-stimulating effect might substitute
1).29,32 With respect to the vascular system, rGLP-1 activation induces modest decreases in blood pressure,33,34 it has a vasodilator effect, improves arterial stiffness, and prevents atherosclerotic plaque formation-and has plaque stabilizing effects-through its anti-inflammatory and antiapoptotic effects as demonstrated in animal models.29,32,3538 Despite controversies about rGLP-1 expression in vascular smooth muscle and endothelial cells, studies have shown that arGLP-1 has antiproliferative effects on these cells,39 reduces oxidative stress, improves endothelial function, and increases nitric oxide production in experimental models.3540 In the heart they produce a discrete increase in heart rate (24 beats/min), although this does not seem to be associated with an increase in arrhythmias or cardiovascular events
6 Resesarch on the diabetic retinas of Caenorhabditis elegans suggested that administration of a GLP-1 RA helped protect the organisms retinal vasculature and neuroretinal function
Are there serious risks or rare complications I should know about
The pages linked below present the evidence without reduction
The landmark SURMOUNT trials (SURMOUNT-1, SURMOUNT-2, SURMOUNT-4) reported nausea, vomiting, and gastrointestinal issues as primary side effects, with cold sensitivity not identified as a significant adverse event
