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GLP-1 receptor activation enhances insulin secretion in response to meals, suppresses glucagon release (which reduces hepatic glucose production), slows gastric emptying, and promotes satiety
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People who report disappointing results tend to fit a few patterns: they stopped before completing titration because early nausea convinced them it wasnt working
The article's comparison table notes that because oral semaglutide depends on passing through the stomach, anything that further delays stomach transit can alter how the dose is absorbed
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