Additionally, concurrent use of other medications, unmanaged underlying metabolic conditions, or inconsistent injection technique can blunt the medication's impact on appetite signaling
It works from within
Fluids drop because thirst is also less noticeable
Viruses 7 (Suppl 1), 2536 (2013)
GLP-1s are not going anywhere pharma manufacturers continue to evolve their GLP-1/GIP product offerings (e.g., Eli Lillys Zepbound is the newest on the market), and the number of addressable indications is increasing (e.g., recent clinical evidence that may merit further FDA approval of GLP-1s for cardio-metabolic, nephrological and neurological indications)
Instead, the goal is to prevent severe side effects like nausea or vomiting, which can happen if the initial dose is too high