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Feedback control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes

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Patients with inflammatory bowel disease, diverticular disease, haemorrhoids, recent colorectal surgery, cardiovascular conditions, pregnancy, severe renal or cardiac impairment, coagulopathy, or recent pelvic radiotherapy face heightened risks

It should be emphasized that mitochondrial oxidative stress and dysfunction are the major cellular events associated with AIH