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Sample size was computed on the basis of pilot data and previously published data

HGH (human growth hormone) is a synthetic version that directly elevates GH levels and can have broader systemic effects (3)

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In vitro/ex vivo studies conducted on endothelial cells showed that GLP-1RAs such as exenatide and liraglutide stimulate endothelial NO production and endothelial nitric oxide synthase (eNOS) activation, eliciting vasodilatation through activation of the GLP-1 receptor-dependent AMP-activated protein kinase (AMPK)/protein kinase B (Akt)/eNOS signaling pathway [48,49,50]

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NF-kB pathway inhibition Nuclear Factor-kappa B is one of the master regulators of inflammation in the human body