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In summary, oral administration of iron chelators (especially DFP) provides a non-invasive and promising dosing route for treating brain iron accumulation, but it requires prolonged treatment to achieve effective concentrations, close safety monitoring due to chronic treatment at relatively large dose, and its efficacy might be constrained by peripheral iron binding and the need for sufficient BBB penetration

(i) The hepatic hypersecretion of biliary cholesterol makes bile cholesterol supersaturated and prone to precipitation of solid cholesterol

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[DOI] [PubMed] [Google Scholar] 33.Carvalho M, Remiao F, Milhazes N, Borges F, Fernandes E, Monteiro Mdo C, Goncalves MJ, Seabra V, Amado F, Carvalho F, Bastos ML