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Sterile water is appropriate only for single-use preparations

Not sure whether this was due to improper storage - it needs to be kept cool and in the dark otherwise can degrade - or for some other reason

Alternative poly(A) signals are employed and in some variants, there are internal deletions in some of the domains

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Monograph: Bacteriostatic Water for Injection

In accordance with the theory of the Keap1-Nrf2 system, Keap1-KD mice showed significantly mild pathology of tubular damage, interstitial fibrosis and renal dysfunction (increased serum creatinine level) compared to wild-type mice (Table 1 and Figure 3A) [67]