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Without enough B12, people can face nerve pain and peripheral neuropathy

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A prospective evaluation of this intervention could include a randomized, clinical trial where younger individuals with risk factors suggestive of PD development later in life, such as mutant S (identified via colonic biopsy 8 ) or clinical predictors 77 , would undergo either truncal vagotomy or a placebo intervention at least 10 years prior to any PD diagnosis 8

In those trials, injections were given into the abdomen, upper thigh, or upper arm, with the site rotated each week to minimise local skin reactions such as bruising, redness, or nodule formation

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