Hepatic lipotoxicity creates a pro-inflammatory environment that makes the liver highly susceptible to simultaneous insults, including mitochondrial dysfunction (generating oxidative stress), endoplasmic reticulum stress (Miller et al., 2025
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Eating slowly for improved satiety and digestive comfort also plays a role
Safety Considerations and Who Should Discuss These Alternatives With a Provider GLP-1 and dual-action agonists are contraindicated in personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2
This is because age can affect how well the body absorbs and uses B12
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