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In July 2023, FDA began investigating postmarketing SI/B reports with GLP-1 RAs, issuing a preliminary January 2024 update noting no clear clinical trial signal but uncertainty due to limited cases

For this reason it is recommended that metformin be discontinued for at least 48 h prior to a PET-CT procedure/scan [33, 35]

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Persistence beyond the initial adjustment period warrants clinical review for dose modification or supportive treatment