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When I tried to understand why some people plateau on semaglutide or tirzepatide, the answer usually comes down to receptor adaptation or insufficient coverage of the metabolic pathways driving their specific pattern of weight gain

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A Phase II trial with relatives with a high risk of developing type 1 diabetes indicated a more than 50% risk reduction with teplizumab (HR 0.41 vs placebo) and clinical type 1 diabetes diagnosis was delayed by 1.52 years [31]

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