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The clinical and histologic presentations of melanoma vary greatly, and assessment of uncommon melanomas can be difficult for practitioners because of their scarcity and resemblance to other dermatologic entities

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It majorly occurs on histones 3 and 4 and is controlled by two types of enzymes: histone acetyltransferases (HATs) which add acetyl groups, and histone deacetylases (HDACs) which remove them

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