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Additionally, they attenuate mammalian target of rapamycin (mTOR) activity through the inhibition of AKT-mediated prolin-rich akt substrate (PRAS40) phosphorylation, indicating that GLP-1R agonists (GLP-1RAs) help to control inflammation and immune responses in hCASMCs, improve vascular health, and may positively impact the treatment of atherosclerosis by modulating the AKT and mTOR signaling pathways (Li BY

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A new review explores how GLP-1 receptor agonists may blunt alcohol and drug reward signals, opening a promising but still unproven path toward repurposed treatments for addiction

The GI profile is consistent in character with semaglutide and tirzepatide, though early titration-phase incidence rates appear numerically higher at the 12 mg target dose