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This initial period is all about saturation

However, elevated MMA and homocysteine concentrations may persist in patients with cobalamin concentrations between 200 and 350 pg/mL

The "LR3" in its name has two meanings: L represents molecular weight elongation (Long), and R3 refers to the replacement of the third amino acid from glutamic acid (Glu) to arginine (Arg)

Instead, mitochondrial shrinkage and increased membrane density are often observed [1-2]

105, Honda, Yasushi, et al