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The Nrf2-ARE signaling pathway plays a pivotal role in mediating adaptive cellular responses to oxidative stress [174]

They observed that chronic depletion of mucosal GSH by buthionine sulfoximine (BSO), a specific inhibitor of GCL[47], caused severe degeneration of epithelial cells from jejunum and colon, which was prevented by oral GSH or GSH monoester

The Treated group received a 5-day oral treatment course of 100 mg/kg phenformin (once daily for 5 days, D-2 to D2), whereas the Vehicle group received sterile water

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Throughout the acclimation period, the SD rats had free access to food and water

The in vitro experiments demonstrated the metabolic stability of Tesamorelin