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Short-term or quick weight loss can cause deficiencies as well, but long-term use without a plan can lead to malnourishment, low vitamins, and even hair loss

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Much literature to date has focused on the risk for drug-induced acute pancreatitis attributed to hyperstimulation of acinar cells 14,15

This is often because you are essentially injecting a sub-therapeutic dose

Together with Derek Holdsworth, another gastroenterologist trainee, and Desmond Turner, a biochemist, McIntyre decided to revisit La Barre's hypothesis that the duodenum encouraged the pancreas to produce insulin by releasing incretin

The impact of these factors is further compounded by older age, and presence of comorbidities, as well by pre-existing low muscle mass, sarcopenia, a history of weight recycling and calorie restriction [Fig