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First-generation GHRPs such as GHRP-6 were identified through systematic screening of met-enkephalin analogs and demonstrated potent GH release but with significant off-target effects including appetite stimulation, cortisol elevation, and aldosterone release

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doi: 10.1016/s0300-483x(03)00092-1 56 BaroneGDambrosioAStorelliAGarofaloRBuscoVPStorelliMM