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They take advantage of permeability of the BBB to some cells like leukocytes or immune cells to bring drugs closer to the brain [ Figure 3 (F) ]

The 2-week liraglutide administration did not significantly alter food intake in female SKO mice although there was a slight decrease around day 12 of treatment ( Figure 2C )

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Cross-collaborations among medical institutions at all levels are needed to fully integrate the resources of primary- and higher-level care

The drug creates a positive feedback loop where weight loss improves the metabolic environment, which makes further metabolic normalization easier