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The accumulation of senescent cells, often referred to as the "old cell burden," is a concern because these cells can secrete a variety of harmful substances as part of the senescence-associated secretory phenotype (SASP)

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Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability

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Therefore, the increased Treg frequencies may be a compensatory response to dysfunctional Tregs, but this remains to be tested