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Preclinical (BDNF/TrkB) Dolotov 2006 demonstrated single-administration BDNF and TrkB increases in rat hippocampus the most-cited mechanistic anchor for the nootropic narrative

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Activation of CaMK1 promotes synaptogenesis via phosphorylation of p21-activated kinase interacting exchange factor (PIX), which co-localises with the scaffolding proteins, G-protein-coupled receptor kinase-interacting protein-1 (GIT1) and Shank2, in the postsynaptic density of dendritic spines as part of a multiprotein complex that regulates actin dynamics [94, 99]

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