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9 For a GLP-1 reformulations, the bridging logic might look like this: PK Comparison : Show that your new oral formulation achieves the same Area Under the Curve (AUC) and peak concentration (Cmax) as the RLD injection

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The key is progressive loading: gradually increasing the challenge over time so the muscles continue to receive a growth and maintenance stimulus

doi: 10.3389/fmed.2021.777861 23 HoongCWSChuaMWJ