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Only a small fraction of employer-sponsored health plans (about 20 percent) cover these medications, leaving millions of patients facing either paying the full cost or forgoing treatment

The initial elution was isocratic with 30% acetonitrile for 2 min, followed by a linear gradient for 15 min up to 100% acetonitrile

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Earlier initiation of SGLT2is or GLP-1RAs may provide cardiometabolic protection before the development of advanced disease, whereas longer-standing disease often necessitates combination therapy due to progressive -cell dysfunction and accumulated risk [8]