In one case, a patient regurgitated a significant volume of gastric contents after the induction of anesthesia, despite having ceased taking the medication two days before surgery and fasting from solid foods for 20 hours beforehand.10 This led to the proposal that patients should suspend medication use four weeks prior to surgery.10 Another case involved a patient who, after fasting for 18 hours before the procedure and while on semaglutide, experienced intraoperative pulmonary aspiration.11 A further report detailed a case where an EGD, scheduled as part of bariatric surgery preparations, was canceled due to excessive gastric food retention.12 Collectively, these case reports underscore the potential risks involved with the use of GLP-1 agonists prior to surgical procedures
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To date, the relative contribution of each of these factors to circulating TMAO levels and, therefore, elevated cardiovascular risk remains unclear
Drvenica IT, Stani AZ, Maslovari IS, Trivanovi DI, Ili VL
Additionally, cytotoxic peptide analogs which deliver toxic drugs like doxorubicin directly to cancer cells have shown promise in reducing cancer growth and metastasis
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