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Before SELECT, physicians could reasonably argue that blood pressure and cholesterol improvements might not translate to fewer events

Editor information Editors and Affiliations Rights and permissions Copyright information 2020 Springer Nature Switzerland AG About this chapter Cite this chapter Maselli, D.B., Camilleri, M

Virani SS, Newby LK, Arnold SV, et al

This could be because they need a specific dose, an alternative form (like liquid drops), or a formulation without an ingredient they're allergic to

Formulations of GLP-1 with extended duration The enzyme DPP-4 is responsible for the rapid inactivation of GLP-1, although some GLP-1 is also removed from the circulation by renal clearance and by the enzyme neutral endopeptidase [11]

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