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These effects, in conjunction with potential sleep-enhancing benefits observed in patients with dementia treated with melatonin [214], provide a compelling rationale for hypothesizing that supplementing melatonin near bedtime may augment the glymphatic systems clearance function

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Finally, in addition to this particular effect [47], there is a direct effect on vasomotor tone (i.e., BPC 157 counteracts both L-NAME-induced hypertension and L-arginine-induced hypotension, and there is a specific activation of Src-Caveolin-1-endothelial nitric oxide synthase (eNOS) pathway [43]

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Oren, M