However, its future trajectory is far from linear as many uncertainties remain, e.g., acceptance of obesity as a chronic disease, budget impact faced by payers and health systems willingness and ability to pay, the readout of further cardiovascular outcomes trials after the high profile results of 2023s SELECT trial for Wegovy, or new entrants challenging first generation therapies with alternative mechanisms of action (MoA) to address shortcomings such as gastrointestinal tolerability, current drugs being injectables, or the durability and quality of weight loss which distinguishes between fat and lean body mass
Glutathione acts as a powerful cellular protector
The horizontal position during sleep can worsen sulfur burps and reflux
If eating a full meal feels difficult, shift to smaller and more frequent protein opportunities throughout the day
For patients with a BMI over 35 with obesity-related health conditions, or BMI over 40, bariatric surgery may deliver more durable, life-changing results without the need for lifelong medication
198,205,206 GLP-1 can also enhance the uptake and utilization of glucose in muscle and adipose tissues
)
