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Clinical trials show that GLP-1 users can lose approximately 10% or more of muscle mass during treatment, with roughly 2539% of total weight lost coming from lean body mass rather than fat, according to a 2024 PMC review of strategies for minimizing muscle loss during incretin-based therapy

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doi: 10.1016/j.kint.2016.06.033 117 PrakashS.ChangT

Some patients lose a modest amount while others lose over 100 pounds

Dysbiosis may develop due to a decline in beneficial taxa, while opportunistic species increase